OSLI Retina

December 2016

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1086 Ophthalmic Surgery, Lasers & Imaging Retina | Healio.com/OSLIRetina ■ C L I N I C A L S C I E N C E ■ Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity Aristomenis Thanos, MD; Yoshihiro Yonekawa, MD; Bozho Todorich, MD, PhD; Natalie Huang, BS; Kimberly A. Drenser, MD, PhD; George A. Williams, MD; Michael T. Trese, MD; Antonio Capone Jr., MD BACKGROUND AND OBJECTIVE: To characterize the in vivo microstructural features of patients with history of retinopa- thy of prematurity (ROP). PATIENTS AND METHODS: A single-center, retrospective imaging case series during which a chart review was per- formed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpre- table SD-OCT images were excluded. Main outcome mea- sures included best-corrected visual acuity (BCVA) and ex- ploratory SD-OCT findings. RESULTS: A total of 186 eyes of 112 patients (mean age: 31.5 years; range: 8 years to 70 years) were imaged. Mean visual acuity was 20/150 (range: 20/20 to light perception). Mean foveal thickness (MFT) and subfoveal choroidal thickness (SCT) measured 270.93 µm ± 56.40 µm and 239.87 µm ± 73.00 µm, respectively. There was a negative correlation between ROP stage and MFT (Rho = −0.19; P = .027), but not with SCT (Rho = −0.03; P = .748). There were negative correlations between BCVA and MFT (Rho = −0.23; P < .01) and SCT (Rho = −0.19; P = .04). Ellipsoid zone (EZ) abnor- malities, inner retinal layer thickening, and presence of cho- rioretinal atrophy were associated with higher ROP stage (P < .001) and poorer visual acuity (Rho = 0.59; P < .001). The presence of retinoschisis (n = 36/186; 19%) was as- sociated with poorer visual acuity (P < .001), but did not correlate with higher ROP stage (P = .17). Epiretinal mem- brane-like dense hyaloidal organization and vitreoretinal interface abnormalities were seen in 69% (130/186) and 33% (63/186) of eyes, respectively, but were not associated with ROP stage (P = .87) or visual acuity (P = .54). After controlling for EZ abnormalities, foveal hypoplasia, macu- lar schisis, inner retinal thickening, chorioretinal atrophy, and ROP stage, the independent risk factors for poorer vi- sual acuity were EZ abnormalities (Beta = 0.38; P < .001), chorioretinal atrophy (Beta = 0.18; P = .03), and ROP stage (Beta = 0.22; P < .01). CONCLUSION: SD-OCT imaging identified a variety of mi- crostructural abnormalities present in patients with history of ROP. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:1086-1094.] INTRODUCTION Ever since the original description of retinopathy of prematurity (ROP) by Terry in 1942, 1 the dramatic improvement in neonatal services has led to an overall increase in the prevalence of ROP. 2 Inherently related to the increasing survival rate of premature infants is also the considerable increase in the number of adults currently living with ocular sequelae related to ROP. It has been well established that ROP is associated with a higher incidence of myopia, 3 amblyopia, and strabismus, 4 and prior studies have indicated that adults with history of ROP (hereafter referred to as adult-ROP) have a high risk for premature cataract formation, glaucoma, retinal tears, and rhegmatogenous retinal detachments (RRDs). 5 Late-onset RRDs associated with regressed ROP have been traditionally linked with lower primary anatomic success rates compared to RRDs 6 occurring in individuals without a history of ROP, thus highlighting the complex vitreoretinal interactions occurring in adult ROP. Spectral-domain optical coherence tomography (SD-OCT) allows in vivo, detailed imaging of the retinal microarchitecture with micrometer-level axial resolution. 7 This noninvasive imaging modality has also allowed imaging of the vitreous, 8 vitreoretinal interface, and choroid, 9 which significantly enhanced our understanding about retinal diseases, thus rendering it an indispensable tool in their evaluation and management. In this study, we sought to explore the various SD-OCT features seen in patients with history of regressed ROP. Although several prior studies have demonstrated features of the acute phase of the disease From Associated Retinal Consultants, Royal Oak, MI (AT, YY, BT, KAD, GAW, MTT, AC); and Oakland University William Beaumont Hospital School of Medicine, Auburn Hills, MI (AT, YY, BT, NH, KAD, GAW, MTT, AC). Originally submitted September 28, 2016. Revision received September 28, 2016. Accepted for publication October 10, 2016. The authors report no relevant financial disclosures. Address correspondence to Antonio Capone Jr., MD, Associated Retinal Consultants, William Beaumont Hospital, 3535 West Thirteen Mile Road, Suite 344, Royal Oak, MI 48073; email: acaponejr@arcpc.net. doi: 10.3928/23258160-20161130-02 EXPEDITED REVIEW

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