OSLI Retina

October 2016

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October 2016 ยท Vol. 47, No. 10 953 examination in the left eye (Figure 2). The remaining ophthalmologic exam was unremarkable in both eyes. DISCUSSION The ZIKV outbreak that began in the Northeast of Brazil has already affected 47 countries and territories of the U.S. 3,4 The virus' rapid spread brought tremendous fear due to the clinical manifestations and consequences in babies. As a result, the World Health Organization declared ZIKV disease a Public Health Emergency of International Concern. 6 The Centers of Disease Control (CDC) established recommendations in an attempt to reduce spread of the virus. The CDC advises people, especially Figure 1. MRI of the brain of a baby with congenital Zika infection showing (A) an area of tubular increased T1 signal in the left subcortical white matter of the frontal lobe, suggesting intraparenchymal calcification, and (B) right cortical abnormality compared to contralateral hemisphere, with smooth appearance of the frontal and anterior superior temporal lobes. TABLE Zika Virus and Dengue Fever Virus Workup in Newborn With Congenital Zika Syndrome Test Result Umbilical Cord Blood Zika PCR Negative Umbilical Cord Blood Zika IgM Positive Serum Zika PCR Negative Serum Zika IgM Positive CSF Zika PCR Negative CSF Zika IgM Positive Urine PCR Zika Negative Dengue IgM Cord Blood Negative Dengue IgM Serum Negative Urine Viral Culture Negative IgM = immunoglobulin M; PCR = polymerase chain reaction A B

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