OSLI Retina

October 2016

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October 2016 · Vol. 47, No. 10 901 matched controls. Subjects were also subdivided into subgroups based on type of amblyopia (strabismic and anisometropic) and comparisons were performed among these groups. PATIENTS AND METHODS Study Population This was a cross-sectional, observational study conducted at the American University of Beirut Ophthalmology Department from October 2012 to December 2015. The project was approved by the American University of Beirut Institutional Review Board. Written informed consents were obtained from all patients or from parents/guardians of minor subjects. Assent forms were provided to children and adolescents older than 7 years of age. Fifty patients diagnosed with unilateral amblyopia (strabismic or anisometropic) were enrolled in the amblyopic group. Inclusion criteria included age of 6 years or older but younger than 18 years and a spherical equivalent (SE) refraction less than 7 diopters (D) of hyperopia or myopia. Patients with organic eye disease (history of intraocular surgery, laser treatment, cataract, glaucoma, or retinal disorders) and those not cooperative for OCT examination were excluded. Fifty age- and gender- matched individuals with 20/20 best-corrected vision in both eyes were recruited as a control group. Inclusion criteria for the latter group were subjects with normal ocular examinations, except for possible refractive errors, with SE ranging between –6.00 D and +6.00 D. The control subjects were selected from another study population (after matching for gender and age) and used to determine normative data for choroidal thickness in healthy eyes. Ocular Examination A comprehensive eye exam was performed, including best-corrected visual acuity (BCVA) with Snellen charts, slit-lamp examination, extraocular motility assessment, cycloplegic retinoscopy (30 minutes after instillation of 1% cyclopentolate and 2.5% phenylephrine), and dilated funduscopy. In Figure. Illustrative figure showing how areas were computed. Images were magnified and areas were calculated from the center to 1,500 µm nasally and temporally as follows: nasal area (µm 2 ) = 1,500 * (a + b) / 2 and temporal area (µm 2 ) = 1,500 * (a + c) / 2, with "a" representing the subfoveal choroidal thickness, "b" representing the choroidal thickness taken at 1,500 µm nasally, and "c" representing the choroidal thickness taken at 1,500 µm temporally. Similar measurements were performed inferiorly and superiorly.

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