OSLI Retina

October 2016

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900 Ophthalmic Surgery, Lasers & Imaging Retina | Healio.com/OSLIRetina ■ C L I N I C A L S C I E N C E ■ Choroidal Changes in Anisometropic and Strabismic Children With Unilateral Amblyopia Christiane Al-Haddad, MD; Maamoun Abdul Fattah, MD; Karine Ismail, MSc; Ziad Bashshur, MD BACKGROUND AND OBJECTIVE: To detect changes in the choroidal layer at the macular area in amblyo- pic eyes. PATIENTS AND METHODS: A cross-sectional study of 50 amblyopic patients (20 strabismic and 30 aniso- metropic) and 50 controls was done. Cross-section- al images using enhanced depth optical coherence tomography (OCT) were taken. Thicknesses were measured subfoveally and at 1,500 µm nasally, temporally, inferiorly, and superiorly. Submacular corresponding choroidal areas were also comput- ed. Parameters were compared between amblyopic eyes, fellow eyes, and controls. RESULTS: Significantly thicker choroid was detect- ed in the subfoveal, temporal, and nasal locations (P = .007, .009, and .01, respectively) in amblyopic compared to fellow eyes; areas were also signifi- cantly greater temporally, nasally, and inferiorly. Significant differences in all choroidal measure- ments were found between amblyopic eyes and controls; these persisted only in the anisometropic subgroup. CONCLUSION: Using enhanced depth OCT, the cho- roid of amblyopic eyes was observed to be thicker compared to normal fellow eyes and controls. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:900-907.] INTRODUCTION Advances in optical coherence tomography (OCT) have allowed more detailed assessment of the choroid and its role in retinal diseases. 1 Enhanced depth imaging using spectral-domain OCT (SD-OCT) and the longer-wavelength swept-source OCT (SS-OCT) have been particularly useful in the examination of choroidal anatomy. This increased the available knowledge about the pathophysiology of several ocular conditions, notably in adult chorioretinal pathologies. 2-6 Recently, attention has turned to the pediatric age group. Some studies have looked at point thicknesses, whereas others have looked at choroidal volume using SD-OCT or SS-OCT. One study compared pediatric normal choroidal thicknesses with those of adults. The authors found that macular choroidal thickness was comparable to that in adults, with more difference seen on the temporal side of the fovea. 7 Another study concluded that the macular choroidal thickness and volume were significantly larger among children as compared to adults. 8 Mapelli et al. showed that choroidal thickness increased in early childhood before reaching a plateau in late childhood, and this agreed with Read et al. 9,10 Recently, studies have investigated choroidal thickness in children with amblyopia and found significantly thicker choroids in amblyopic eyes. 11-14 The purpose of this study was to evaluate subfoveal choroidal changes in patients with amblyopia. We compared the subfoveal choroidal thicknesses and area in the amblyopic eye with the fellow eye and with eyes of normal age-matched and gender- From the Department of Ophthalmology, American University of Beirut, Beirut, Lebanon. Originally submitted April 12, 2016. Revision received July 22, 2016. Accepted for publication August 17, 2016. The authors report no relevant financial disclosures. Address correspondence to Ziad Bashshur, MD, Professor, Vitreoretinal Service, Department of Ophthalmology, American University of Beirut Medical Cen- ter, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Beirut, Lebanon; email: zb00@aub.edu.lb. doi: 10.3928/23258160-20161004-02

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