OSLI Retina

February 2021

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111 © Ophthalmic Surgery, Lasers & Imaging Retina News and Notes Faricimab Meets Primary Endpoints in Phase 3 Wet AMD Studies Faricimab met its primary endpoint in two phase 3 studies, with injections every 16 weeks achieving noninferior visual acuity outcomes compared aflibercept every 8 weeks in wet age-related macular degeneration, according to a press release. In the TENAYA and LUCERNE studies, 45% of participants were dosed with faricimab (Genentech, South San Francisco, CA) every 16 weeks in the first year. Subjects achieved noninferior visual acuity outcomes compared with patients who received Eylea (aflibercept; Regeneron, Tarrytown, NY) injections every 8 weeks, the release said. In addition, faricimab presented no new or unexpected safety signals. The identical, randomized, multicenter, double-masked, global studies are evalu- ating the efficacy and safety of faricimab in 1,329 subjects with wet AMD. "We have now seen positive and consistent results in four phase 3 studies for faricimab across both neovascular age-related macular degeneration and diabetic macular edema," Levi Garraway, MD, PhD, chief medical officer and head of global product development at Genentech, said in the release. "We look forward to submit- ting these data to global regulatory authorities, with the aim of bringing this promis- ing treatment option to patients as soon as possible." Positive results were reported earlier for the YOSEMITE and RHINE phase 3 stud- ies in diabetic macular edema. Originally published on www.Healio.com on January 25, 2021. Ophthalmic Surgery, Lasers & Imaging Retina® (ISSN-2325-8160, Canadian BN-12978 0466 RT ) is published 12 times per year by SLACK Incorporated, and is the official journal of Retina World Congress. Publication Office: SLACK Incorporated, 6900 Grove Road, Thorofare, NJ 08086-9447. Telephone (856) 848-1000. Printed in the USA. 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See website for print and web advertising policy. Readers with queries about the Journal's policies on error correction, version control, journal of record, ancillary material, or archiving should contact osli@healio.com. The Journal staff have no financial relationships to disclose. Financial disclosures for the Editor and members of the Editorial Board are on file with the editorial office. Indexed in: Medline/PubMed, ProQuest, EMCare, EMBASE, Science Citation Index, Current Contents/Clinical Medicine, BioEn- gineering Abstracts, CAB Abstracts, and SCOPUS. Follow OSLIJournal OSLI Retina SLACK Incorporated 6900 Grove Road Thorofare, NJ 08086-9447 Phone: 856-994-9900 Email: osli@healio.com SLACK Incorporated EDITORIAL Senior Vice President Stephanie Arasim Portnoy Vice President, Editorial Jennifer A. Kilpatrick, ELS Director, Electronic Publishing & Production Karen G. 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