OSLI Retina

March/April 2013

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■ C A S E Non-leaking Cystoid Maculopathy Secondary to Systemic Paclitaxel Dimple Modi, MD, MPH; Sander R. Dubovy, MD R E P O R T ■ INTRODUCTION Cystoid macular edema without evidence of leakage on fluorescein angiogram has been reported to be associated with the taxane class of medications. There are a few cases reported in the literature that demonstrate this phenomenon after systemic chemotherapy with paclitaxel and docetaxel.1 To our knowledge, this is the first case reported to demonstrate complete resolution of cystoid macular edema (CME) after cessation of the drug. CASE REPORT ABSTRACT: Taxane-associated maculopathy is scarcely reported in the literature but should be considered as a known complication of intravenous use of the chemotherapy medication to ophthalmologists as well as primary care physicians and oncologists. We report a case of paclitaxel maculopathy in a 61-year-old female who received treatment with this drug for metastatic breast cancer. This is the first known case to report complete resolution of the maculopathy after cessation of the drug. [Ophthalmic Surg Lasers Imaging Retina. 2013;44:183-186] From Bascom Palmer Eye Institute, Miami, Florida. Originally submitted August 2, 2012. Accepted for publication November 29, 2012. Posted onilne February 22, 2013. The authors have no financial or proprietary interest in the materials presented herein. Address correspondence to Dimple Modi, MD, MPH, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136. doi: 10.3928/23258160-20130218-01 March/April 2013 • Vol. 44, No. 2 A 61-year-old Caucasian woman presented with a 3-month history of blurry vision in both eyes. Her medical history included invasive ductal carcinoma with one positive lymph node. Four years after diagnosis of the primary breast cancer, she developed a right hilar mass. Hilar lymph node biopsy and middle lung lobe biopsy were performed. The diagnosis of carcinoid tumor was made, the tumor was resected, Figure 1. (A) Photomicrograph of carcinoid tumor from hilar lymph node biopsy. The margins were free of tumor (hematoxylin and eosin stain; original magnification ×4). (B) Further magnification reveals nests of medium-sized polygonal cells of low nuclear grade with round to oval finely granular nuclei and lightly eosinophilic cytoplasm, typical of carcinoid (hematoxylin and eosin stain; original magnification ×20). (C) Individual cells are regular with uniform round nuclei, and this magnified view better demonstrates the presence of goblet cells (hematoxylin and eosin stain; original magnification ×40). 183

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