OSLI Retina

February 2020

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124 Ophthalmic Surgery, Lasers & Imaging Retina | Healio.com/OSLIRetina ■ I M A G E S I N O P H T H A L M O L O G Y ■ Pigmented Ocular Fundus Lesions Associated With Familial Adenomatous Polyposis Chris J. Li, BS; Antonio Yaghy, MD; Carol L. Shields, MD A 36-year-old man was referred for evaluation after trauma to the left eye. He gave a history of familial ad- enomatous polyposis (FAP) diagnosed at age 15 years and treated with prophylactic colectomy. Fundus- copy revealed multifocal pigmented ocular fundus lesions at the level of the retinal pigment epithelium (RPE) in both eyes (Figure 1A and 1B). The lesions were haphazardly distributed, oval-shaped, variable in size, and with irregular borders. On fundus auto- fluorescence, the RPE lesions were hypoautofluores- cent and surrounded by trace hyperautofluorescence (Figure 1C and 1D). These findings represented the pigmented ocular fundus lesions that serve as a bio- marker for FAP. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:124.] From the Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia. Originally submitted August 28, 2019. Revision received August 28, 2019. Accepted for publication October 29, 2019. Support provided in part by the Eye Tumor Research Foundation, Philadelphia, PA (CLS). The funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript. Dr. Shields has had full access to all the data in the study and takes responsibility for the integrity of the data. The authors report no relevant financial disclosures. Address correspondence to Carol L. Shields, MD, Ocular Oncology Service, 840 Walnut Street, Suite 1440, Philadelphia, PA 19107; email: carolshields@ gmail.com. doi: 10.3928/23258160-20200129-10 Figure 1. (A, B) Multifocal pig- mented ocular fundus lesions at the level of the retinal pigment epithelium (RPE) were seen in both eyes on funduscopy. (C, D) Retinal pigment epithelium lesions appeared to be hypoautofluores- cent and were surrounded by trace hyperautofluorescence on fundus autofluorescence imaging.

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